Historical Stock Price
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Video: Compound Annual Growth Rate (CAGR) Definition
Date Open High Low Close Volume
10/09/2026 $0.60 $0.62 $0.56 $0.60 963.00K
10/12/2026 $0.59 $0.60 $0.50 $0.51 895.10K
10/13/2026 $0.49 $0.50 $0.40 $0.43 1.75M
10/14/2026 $0.43 $0.43 $0.32 $0.32 2.08M
10/15/2026 $0.31 $0.35 $0.31 $0.35 1.33M
Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. Co. is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. It is developing and commercializing small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy.
KPTI historical stock prices picture
Karyopharm Therapeutics (KPTI) has the following price history information. Looking back at KPTI historical stock prices for the last five trading days, on October 09, 2026, KPTI opened at $0.60, traded as high as $0.62 and as low as $0.56, and closed at $0.60. Trading volume was a total of 963.00K shares. On October 12, 2026, KPTI opened at $0.59, traded as high as $0.60 and as low as $0.50, and closed at $0.51. Trading volume was a total of 895.10K shares. On October 13, 2026, KPTI opened at $0.49, traded as high as $0.50 and as low as $0.40, and closed at $0.43. Trading volume was a total of 1.75M shares. On October 14, 2026, KPTI opened at $0.43, traded as high as $0.43 and as low as $0.32, and closed at $0.32. Trading volume was a total of 2.08M shares. On October 15, 2026, KPTI opened at $0.31, traded as high as $0.35 and as low as $0.31, and closed at $0.35. Trading volume was a total of 1.33M shares.

KPTI Historical Stock Prices By Date:

KPTI historical cagr picture

Below, we examine the compound annual growth rate — CAGR for short — of an investment into Karyopharm Therapeutics shares, starting with a $10,000 purchase of KPTI, and working forward through the historical stock price information to today.

Growth of $10,000.00
Without Dividends Reinvested

Start date: 10/18/2016
End date: 10/15/2026
Start price/share: $129.30
End price/share: $0.35
Dividends collected/share: $0.00
Total return: -99.73%
Average Annual Total Return: -44.63%
Starting investment: $10,000.00
Ending investment: $27.13
Years: 10.00
Date Close
10/09/2026$0.60
10/12/2026$0.51
10/13/2026$0.43
10/14/2026$0.32
10/15/2026$0.35
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Also explore: KPTI shares outstanding history

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